Plyomavirus are of 2 types,JC and BK. They frequently cause inapparent persistent infections, whichmay reactivate under immunosupression and then result in overt disease. JC virus causes a rare but serious demyelinating disease, progressive multifocal leukoencephalopathy (PML), whereas reactivation of BK virus may result in haemorrhagic urnary tract infections especiallyin transplant patients. BKV and JCV also induces tumours if inoculated into newborn hamsters.
Simian vaculating virus (SV40) is another polyoma virus that can replicate in monkey and human cells. It is highly tumourigenic expermientaly in hamsters and can transform tissue culture cells
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