leprosy
.the exact mode of ytranmission os not known
.infection requires prolonged and closed contact with ptients
. chronic infectious disease that primarily affect cooler surface area of the body such as skin ear lobes
.usually some of irreversible nerve damage
.
a) Tuberculoid leprosy
- cell-mediated immune response predominates and form granulomas so destruct most of mycobacteria
- so only few remain in the tissue
- lesions are few and mainly in the hypopigmented maculo-anesthetic skin lesions
- spontaneous regression of tuberculid leprosy occur in 90 % of cases
b)Lepromatous leprosy
- cell-mediated immune response is depressed
- humoral response is dominating but not protective as the organism is intracellular
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