treponema pallidum

syphilis

-1ry syphilis
a) manifested as single hard, painless ulcer called chancre

b) ip 10-60 days

c) chancre represent the 1ry site of initial multiplication

d) usually appears on the penis, labia, cervix, anorectal region, or around the mouth

e) regional lymph nodea also becomes enlarged

d) the chancre heals within 4-6 weeks even without treatment

-2ry syphilis ( four cardinal features)

a) generalized skin rash

b) mucous patches in mouth and throat

c) chondyloma lata ( moist papules) form around the genitals or anus

d) generalized lymphadenopathy

* the symptoms usually last 3-6 months and disappear spontaneously

-the latent (hidden) stage

a) no symptoms neither lesion

b) serology is positive

c) range from a few months to a life time

-tertiary syphilis

a) 40 % of untreated case

b) characterized by gumma formation

c) lead to cardiovascular syphilis

d) serology is positive

-congenital syphilis

a) can lead to a stillbirth

b)